Table 1 The study of miRNA in stem cell EVs for AKI
Study | Animal | Model | Stem cell source | Route of administration | Method | miRNA | Result |
|---|---|---|---|---|---|---|---|
Gatti et al. 2011 [12] | Rat | IRI | Human bone marrow | IV | Pretreatment of MVs with RNase | miRNA | Reduce TECs apoptosis and increase TECs proliferation |
Collino et al. 2015 [4] | Rat | Glycerol | Human bone marrow | IV | RNA-Seq, Drosha-Knockdown MSCs | miRNA | Anti-inflammation |
Wang et al. 2016 [28] | Mouse | UUO | Human bone marrow | IV | Engineered to overexpress miRNA-let7c | miRNA-let7c | Alleviate kidney fibrosis |
Wang et al. 2015 [19] | Mouse | UUO | Mice primary bone marrow | IV | MicroRNA profiling arrays | miRNA | Enhanced inhibition of EMT |
Wang et al. 2015 [19] | HK-2 | TGF-β1-mediated | Rat bone marrow |  | miRCURY LNA Array miRNA treatment | miR-133b-3p miR-294 | Inhibited TGF-β1-mediated EMT |
Yuan et al. 2017 [34] | Mouse | IRI | Mice bone marrow | IV | miR-223 knockdown | miR-223 | Downregulation of NLRP3, suppressed apoptosis |
Zhu et al. 2019 [36] | Mouse | IRI | Human bone marrow | IV | Overexpression or knockdown of miR-199a-3p | miR-199a-3p | Restore Sema3A expression and blocke the activation of the AKT and ERK pathways, antiapoptosis |
Zou et al. 2014 | Rat | IRI | Human umbilical cord | IV | CX3CL1 in the TargetScan database, PCR | miR-15a, miR-15b and miR-16 | Cell proliferation , Antifibrosis |
Gu et al. 2016 [43] | Rat | IRI | Human umbilical cord | IV | miR-30 antagomir treat MSC | miR30 | Antiapoptosis, Preserved mitochondrial,morphology |
Cantaluppi et al. 2012 | Rat | IRI | Endothelial progenitor cells EPC | IV | miRNA array, anti-miR126 and anti-miR-296 antagomiRs | miR-126 and miR-296 | Enhancement of cell proliferation,Decrease in tubular cell apoptosis and leukocyte infiltration |
Vinas et al. 2016 [51] | Rat | IRI | Human cord blood endothelial colonyforming cells | IV | Truseq Small RNA kit antagomiR to miR-486-5p | miR-486-5p | Target at PTEN/Akt pathway |
Pang et al. 2017 [52] | Rat | IRI | Human renal artery-derived vascular progenitor cells | IV | miRNA microarray LNA-miR218 | miR-218 | Enhance endothelial cell migration |