Skip to main content
Fig. 10 | Stem Cell Research & Therapy

Fig. 10

From: PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

Fig. 10

Overexpression of PBX1 inhibited the AKT/GSK3β signaling pathway to promote apoptosis during reprogramming. a Apoptosis in SOMK-transduced HF-MSCs and SOMKP-transduced HF-MSCs cultured with LY294002 during reprogramming on days 7 and 21. b Quantitative analysis of the proportion of early apoptotic cells (APC Annexin V+ and 7-AAD-). c Quantitative analysis of the proportion of late apoptotic cells (APC Annexin V+ and 7-AAD+). d Western blotting analysis of the expression of apoptosis-related proteins (BCL-2, BAX, caspase3, and PARP1) in transduced HF-MSCs during reprogramming on days 7 (e) and 21 (f). g Caspase3 activity in transduced HF-MSCs during reprogramming on day 21, shown as the fold change compared with the control. The value for SOKM-transduced HF-MSCs as the control group was set as 1.0. *P < 0.05; **P < 0.01; ***P < 0.001

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512