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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

Fig. 8

PBX1 reduced apoptosis during the early stage of reprogramming. a Apoptosis of transduced HF-MSCs on reprogramming day 7. b Quantitative analysis of the proportion of early apoptotic cells (APC Annexin V+ and 7-AAD−). c Quantitative analysis of the proportion of late apoptotic cells (APC Annexin V+ and 7-AAD+). d, e Western blotting was used to detect the expression of apoptosis-related proteins (BCL-2, BAX, Caspase3, and PARP1) in transduced HF-MSCs on reprogramming day 7. f Caspase3 activity in transduced HF-MSCs on reprogramming day 7 is shown as the fold change compared with the control. The value in SOMK-transduced HF-MSCs as the control group was set as 1.0. *P < 0.05; **P < 0.01; ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512