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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

Fig. 9

Knockdown of PBX1 promoted apoptosis during reprogramming. a Apoptosis in transduced HF-MSCs during reprogramming on day 21. b Quantitative analysis of the proportion of early apoptotic cells (APC Annexin V+ and 7-AAD−). c Quantitative analysis of the proportion of late apoptotic cells (APC Annexin V+ and 7-AAD+). d, e Western blotting analysis of the expression levels of apoptosis-related proteins (BCL-2, BAX, caspase3, and PARP1) in transduced HF-MSCs during reprogramming on day 21. f Caspase3 activity in transduced HF-MSCs during reprogramming on day 21, shown as the fold change compared with the control. The value for SOMK-transduced HF-MSCs as the control group was set as 1.0. *P < 0.05; **P < 0.01; ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512