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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens

Fig. 3

Transplantation of ICAM-1-overexpressing MSCs remarkably alleviated the pathological damage in the colon of IBD mice. The colon structure was almost intact and only a few lymphocytes are detected in the lamina propria in healthy animals; however, severe inflammatory cell infiltration was observed in the villi and lamina propria in the colon of IBD mice. Conversely, MSC infusion reduced the pathological damage in IBD mice and only mild edema of lamina propria and submucosa and a small number of inflammatory cell infiltrations was observed in the colon (a). The inflammatory cells in the pictures are shown by arrows. Additionally, the results of pathological scores (Scheiffele criteria) showed that infusion of ICAM-1-overexpressing MSCs remarkably ameliorates the tissue damage (b). Bars in a represent 500 μm. (*, P < 0.05)

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