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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Autograft microskin combined with adipose-derived stem cell enhances wound healing in a full-thickness skin defect mouse model

Fig. 2

Microscopic appearance of wound beds post-surgery. a Hematoxylin and eosin staining of wound beds at day 14 post-surgery. Wounds treated with MS+ADSC showed a newly formed, hyperplastic epithelium that covered the wound area. The black arrows indicate the microskin grafts had become appendages of the newly formed skin. The asterisks indicated normal adnexal structures. “N” is represented for normal skin, and “w” is represented for wound area. b α-SMA staining of wound beds at day 14 post-treatment. At day 14, the expression of α-SMA in wound tissue was decreased in the MS+ADSC group compared to others. Scale bars are 100 and 500 μm. c CD31 staining of the wound area at days 7 and 14 after treatment. Black arrows indicate CD31-positive vessels. d the number of CD31-positive (+) blood vessels per high-power fields (HPFs) (× 20) were quantified to a particular time point. The data expressed are the average means ± SEM, n = 5. ****p < .0001, compared to the ADSC group, MS group, and control group; **p < .01; *p < .05; ns, not significant, compared to the control group

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