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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: iPSC-derived MSC therapy induces immune tolerance and supports long-term graft survival in mouse orthotopic tracheal transplants

Fig. 2

iPSC-derived MSC therapy increased infiltration of Treg in allograft. a Immunofluorescent staining for subepithelial human TSG-6 expression at d10 post transplantation. b Immunofluorescent staining for CD4+FOXP3+ lymphocytes at d10 post transplantation. ce Morphometric analysis of graft infiltrating CD4+ T cells, FOXP3+ cells, and CD4+FOXP3+ co-localization (Tregs). Arrows highlighted individual CD4+ T cells (white arrows), FOXP3+ cells (blue arrows), and CD4+FOXP3+ Treg cells (yellow arrows). Data are presented as means with SE of 12 transplants/time point/experiments. *p < 0.05. Original magnification, × 40

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