Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

Table 2 Overview of gene-transfected MSC studies conducted in in vitro and in vivo models

MSC origin	Model	In vivo/in vitro potency	Transgene	Ref.
H - BM	Glioblastoma	Increased survival in glioma stem cell-injected mice	miR-124a	[144]
H - BM	Breast cancer	Decreased tumor activity and size	miR-379	[145]
H - BM	Renal fibrosis	Decreased matrix deposition	miR-let-7c	[108]
H - SYN	Diabetes skin defect	Increased proliferation of fibroblasts and epithelial cells	miR-126	[117]
H - SYN	Osteoarthritis	Increased cartilage tissue regeneration	miR-140-5p	[116]
H - UC	Glioblastoma (in vitro)	Decreased proliferation and migration and increased chemosensitivity	miR-124	[111]
H - UC	Burn-induced inflammation	Decreased inflammation	miR-181c	[146]
H/M - AD	Liver fibrosis	Inhibited fibrosis	miR-122	[109]
H/M - AD	Hepatocarcinoma	Inhibited tumor growth	miR-122	[110]
Marrow stromal cells	Glioma	Inhibited tumor growth	miR-146b	[112]
M - AD	Liver fibrosis	Increased autophagy	miR-181-5p	[147]
M - BM	Autoimmune hepatitis	Recovery from liver injury	miR-223	[115]
R - BM	Myocardial infarction	Improved cardiac function and reduced infarction size	miR-19a	[100]
R - BM	Cortical neuron activation (in vitro)	Increased axonal growth	miR-17-92	[113]
R - BM	Intracerebral hemorrhage	Neuroprotective effects	miR-133b	[114]
R - BM	Acute myocardial infarction	Increased cardiac function	miR-133	[148]
R - BM	Cardiomyocyte activation (in vitro)	Increased survival after hypoxia in cardiomyocytes	miR-221	[149]

Abbreviations: MSC mesenchymal stem cell, H human, M mouse, R rat, BM bone marrow, AD adipose tissue, UC umbilical cord, SYN synovial

ISSN: 1757-6512