Fig. 4
From: A novel construct with biomechanical flexibility for articular cartilage regeneration
Histological and biomechanical examination of cartilage tissue regenerated in the subcutis of nude mice using the BMSC/PRF construct. a HE staining of specimens from nude mice. a–c BMSC sheet group at 2, 4, and 8 weeks, respectively; d–f BMSC/PRF construct group at 2, 4, and 8 weeks, respectively; and g–i pressure-pretreated BMSC/PRF construct group at 2, 4, and 8 weeks, respectively (red arrow indicates the implanted cartilage fragment; × 100, bar = 100 μm). b Toluidine blue staining of specimens from nude mice. a–c BMSC sheet group at 2, 4, and 8 weeks, respectively; d–f BMSC/PRF construct group at 2, 4, and 8 weeks, respectively; and g–i pressure-pretreated BMSC/PRF construct group at 2, 4, and 8 weeks, respectively (red arrow indicates the implanted cartilage fragment; × 100, bar = 100 μm). c Image analysis of toluidine blue staining intensity of specimens from nude mice. aP < 0.05, vs. BMSC sheet transplantation group; bP < 0.05, vs. no-pressure BMSC/PRF transplantation group