Fig. 5
From: A novel construct with biomechanical flexibility for articular cartilage regeneration
Histological and biomechanical examination of in situ regeneration and repair of condylar cartilage defects in rabbit using the BMSC/PRF construct. a Gross morphology of rabbit condyle (scale bar = 5 mm). b HE staining of rabbit condyle (× 40, bar = 250 μm). c Toluidine blue staining of rabbit condyle; a, g, and m control group at 2, 4, and 8 weeks, respectively; b, h, and n PRF group at 2, 4, and 8 weeks, respectively; c, i, and o BMSC group at 2, 4, and 8 weeks, respectively; d, j, and p BMSC/PRF group at 2, 4, and 8 weeks, respectively; e, k, and q pressure-pretreated BMSC/PRF construct group at 2, 4, and 8 weeks, respectively (× 40, bar = 250 μm). d Statistical analysis of GAG/DNA ratio of each specimen. e Morphological scores of repair tissue in rabbit condylar cartilage defects. aP < 0.05, vs. control group; bP < 0.05, vs. PRF transplantation group; cP < 0.05, vs. BMSC sheet transplantation group; dP < 0.05, vs. no-pressure BMSC/PRF transplantation group