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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: S100B is required for maintaining an intermediate state with double-positive Sca-1+ progenitor and vascular smooth muscle cells during neointimal formation

Fig. 6

S100B maintains an intermediate state of double-positive Sca-1+ stem cells and VSMCs through SDF-1α/CXCR4. This experiment was designed to demonstrate the role of SDF-1α/CXCR4 axis in maintaining an intermediate state of stem cells and VSMCs in the injured vessels and attempted to show indirect confirmation of the relationship between the role of S100B and intermediate state, likely involving SDF-1α/CXCR4. a, b Typical image of immunofluorescence double staining for Sca-1 and α-SMA in injured arteries treated with or without AMD3100 for 14 days. Red fluorescence indicates Sca-1, green fluorescence indicates α-SMA, and blue fluorescence indicates DAPI-labeled nucleus. Round arrow indicates lumen-side neointima, open arrow indicates media-side neointima, diamond arrow indicates the media, and forked tail arrow indicates the adventitia. c, a The number of double-positive cells with Sca-1 and α-SMA within the media or intima (seen in a, b) was determined by image-Pro Plus software. n = 6, &P < 0.05 vs. the injured arteries treated with Ad-Null

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Stem Cell Research & Therapy

ISSN: 1757-6512