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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model

Fig. 1

Rhesus macaques presenting an early stage of DN. a Timeline of the study. b Histological staining of renal tissues. Glomerular hypertrophy, tubular dilatation, and peritubular interstitial fibrosis were indicated by arrows. c TEM of renal tissues. Thickened glomerular basement membranes are indicated by red arrow and asterisk. dg Quantified renal histological indices at baseline and 2 years later. GBM: glomerular basement membrane; Normal: normal and nondiabetic rhesus macaques; DN: rhesus macaques with diabetic nephropathy. Scale bar = 50 μm. Magnification of TEM: 1.2 k. Each bar represents the mean ± s.e.m. Four fields of each section, four sections per rhesus macaque were observed and quantified, and the number of rhesus macaques analyzed in each group: Normal (n = 3), DN (n = 12). ****p < 0.0001: normal group versus DN group after 2 years

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