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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model

Fig. 8

Effects of MSCs on inflammation and SGLT2 expression of HK2. HK2 cells with and without co-culture of MSCs or canagliflozin were treated with GT for 72 h. a The effects of canagliflozin on HK2 cell viability. b The levels of glucose in culture medium of HK2 cells analyzed by an oxidase method. c Effects of MSCs and canagliflozin on ATP level of GT-treated HK2 cells. d Western blot analysis of protein expression levels after MSC and canagliflozin intervention. e Immunostaining of FN, SGLT2, and p-NF-КB p65 in HK2 cells. f Quantification of Western blot analysis of protein expressions. Can: canagliflozin. Each bar represents the mean ± s.e.m., n ≥ 3/group. *p < 0.05; **p < 0.01; ***p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512