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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model

Fig. 9

The hypothetical pathway through which MSC infusion ameliorate the development of DN. Preclinical nonhuman primate model of diabetic nephropathy (DN) was built by streptozotocin (STZ) injection and a high-salt and high-fat diet to rhesus macaque. Mesenchymal stem cells (MSCs) transplantation ameliorated diabetic nephropathy compared with normal saline (NS) infusion. The possible mechanisms were investigated by exploring the effects of MSCs on anti-inflammation and Na+-glucose cotransporter 2 (SGLT2) expression on tubular epithelial cells

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Stem Cell Research & Therapy

ISSN: 1757-6512