Fig. 3

The regulating mechanisms of ncRNAs that contribute to the odontogenic differentiation of dental tissue-derived stem cells. The green arrow indicates promotion, and the red T indicates inhibition. ALP, alkaline phosphatase; BMP4, bone morphogenetic protein 4; COL-I, collagen type 1; DLX3, distal-less homeobox 3; DNMT3B, DNA methyltransferase 3B; DMP1, dentin matrix acid phosphoprotein 1; DSPP, dentin sialophosphoprotein; H19, imprinted maternally expressed transcript; HES, hairy/enhancer of split; IGF-1, insulin-like growth factor-1; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MAPKK, mitogen-activated protein kinase kinase; N2ICD, Notch2 intracellular domain; NICD, Notch intracellular domain; OCN, osteocalcin; OPG/RANKL, osteoprotegerin/receptor activator of the nuclear factor-κB ligand; OPN, osteopontin; OSX, osterix; RUNX2, runt-related transcription factor 2; SAHH, S-adenosylhomocysteine hydrolase; SMAD3, SMAD family member 3; SPAG9, sperm-associated antigen 9; STAT3, signal transducer and activator of transcription 3; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α; TLR-4, Toll-like receptor 4