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Table 2 Noncoding RNAs involved in the odontogenic differentiation of dental tissue-derived mesenchymal stem cells

From: Noncoding RNAs: new insights into the odontogenic differentiation of dental tissue-derived mesenchymal stem cells

ncRNA

Gene ID

Effects

Modes of action

Associated targets or pathways

Cell category

References

lncRNA

H19 (imprinted maternally expressed transcript)

Promotes odontogenic differentiation

(1) H19/SAHH axis

DNMT3B decreases and DLX3 increases

Human DPSCs

Zeng et al. 2018 [70, 71]

(2) H19/miR-141/SPAG9 axis

p38 and JNK MAPK pathway

Human SCAPs

Li et al. 2019 [72]

lncRNA

DANCR (differentiation antagonizing nonprotein coding RNA)

Blocks odontoblast-like differentiation

GSK-3β and β-catenin suppression

Canonical Wnt/β-catenin signaling pathway

Human DPCs

Chen et al. 2016 [65]

miRNA

miR-21

Positively modulates odontoblastic differentiation

(1) Increasing p-STAT3

A positive feedback loop in the miR-21/STAT3 signaling pathway

Human DPSCs

Xu et al. 2018 [50]

(2) Increased by p-STAT3

miRNA

miR-143-5p

Inhibits the differentiation of human DPSCs into odontoblasts

(1) Interacting with RUNX2 3′-UTR

(1) RUNX2 suppression OPG/RANKL signaling pathway

Human DPSCs

Zhan et al. 2018 [54]

(2) Interacting with the MAPK14 3′-UTR

(2) MAPK14 suppression p38 MAPK signaling pathway

Wang et al. 2019 [55]

miRNA

miR-140-5p

Inhibits odontogenic differentiation

Interacting with the TLR-4 3′-UTR

LPS/TLR-4 signaling pathway

Human DPSCs

Sun et al. 2017 [56]

miRNA

miR-223-3p

Promotes odontoblastic differentiation

Interacting with the BMP4 3′-UTR

SMAD3 suppression TGF-β1 signal transduction pathway

Human DPSCs

Huang et al. 2019 [51]

miRNA

miR-448

Blocks odontogenic differentiation

Interacting with the MAPK1 3′-UTR

p38 MAPK signaling pathway

Human DPSCs

Yu et al. 2019 [57]

miRNA

hsa-let-7c

Inhibits the odontogenic differentiation of IGF-1-treated human SCAPs

IGF-1/IGF-1R/hsa-let-7c axis

JNK and p38 MAPK signaling pathways

Human SCAPs

Ma et al. 2016 [32]

miRNA

miR-34a

Promotes odontogenic differentiation

(1) Interacting with NOTCH2 and HES1 3′-UTR

Crosstalk between miR-34a and Notch signaling

Human SCAPs

Sun et al. 2014 [52]

(2) Activated by Notch signaling

  1. ALP alkaline phosphatase, BMP4 bone morphogenetic protein 4, COL-I collagen type 1, DLX3 distal-less homeobox 3, DNMT3B DNA methyltransferase 3B, DMP1 dentin matrix acid phosphoprotein 1, DSPP dentin sialophosphoprotein, GSK-3β glycogen synthase kinase 3, HES hairy/enhancer of split, IGF-1 insulin-like growth factor-1, JNK c-Jun N-terminal kinase, LPS lipopolysaccharide, MAPK mitogen-activated protein kinase, N2ICD Notch2 intracellular domain, NICD Notch intracellular domain, OCN osteocalcin, OPG/RANKL osteoprotegerin/receptor activator of the nuclear factor-κB ligand, OPN osteopontin, OSX osterix, RUNX2 runt-related transcription factor 2, SAHH S-adenosylhomocysteine hydrolase, SMAD3 SMAD family member 3, SPAG9 sperm-associated antigen 9, STAT3 signal transducer and activator of transcription 3, TGF-β transforming growth factor-β, TNF-α tumor necrosis factor-α, TLR-4 Toll-like receptor 4