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Table 2 Noncoding RNAs involved in the odontogenic differentiation of dental tissue-derived mesenchymal stem cells

From: Noncoding RNAs: new insights into the odontogenic differentiation of dental tissue-derived mesenchymal stem cells

ncRNA Gene ID Effects Modes of action Associated targets or pathways Cell category References
lncRNA H19 (imprinted maternally expressed transcript) Promotes odontogenic differentiation (1) H19/SAHH axis DNMT3B decreases and DLX3 increases Human DPSCs Zeng et al. 2018 [70, 71]
(2) H19/miR-141/SPAG9 axis p38 and JNK MAPK pathway Human SCAPs Li et al. 2019 [72]
lncRNA DANCR (differentiation antagonizing nonprotein coding RNA) Blocks odontoblast-like differentiation GSK-3β and β-catenin suppression Canonical Wnt/β-catenin signaling pathway Human DPCs Chen et al. 2016 [65]
miRNA miR-21 Positively modulates odontoblastic differentiation (1) Increasing p-STAT3 A positive feedback loop in the miR-21/STAT3 signaling pathway Human DPSCs Xu et al. 2018 [50]
(2) Increased by p-STAT3
miRNA miR-143-5p Inhibits the differentiation of human DPSCs into odontoblasts (1) Interacting with RUNX2 3′-UTR (1) RUNX2 suppression OPG/RANKL signaling pathway Human DPSCs Zhan et al. 2018 [54]
(2) Interacting with the MAPK14 3′-UTR (2) MAPK14 suppression p38 MAPK signaling pathway Wang et al. 2019 [55]
miRNA miR-140-5p Inhibits odontogenic differentiation Interacting with the TLR-4 3′-UTR LPS/TLR-4 signaling pathway Human DPSCs Sun et al. 2017 [56]
miRNA miR-223-3p Promotes odontoblastic differentiation Interacting with the BMP4 3′-UTR SMAD3 suppression TGF-β1 signal transduction pathway Human DPSCs Huang et al. 2019 [51]
miRNA miR-448 Blocks odontogenic differentiation Interacting with the MAPK1 3′-UTR p38 MAPK signaling pathway Human DPSCs Yu et al. 2019 [57]
miRNA hsa-let-7c Inhibits the odontogenic differentiation of IGF-1-treated human SCAPs IGF-1/IGF-1R/hsa-let-7c axis JNK and p38 MAPK signaling pathways Human SCAPs Ma et al. 2016 [32]
miRNA miR-34a Promotes odontogenic differentiation (1) Interacting with NOTCH2 and HES1 3′-UTR Crosstalk between miR-34a and Notch signaling Human SCAPs Sun et al. 2014 [52]
(2) Activated by Notch signaling
  1. ALP alkaline phosphatase, BMP4 bone morphogenetic protein 4, COL-I collagen type 1, DLX3 distal-less homeobox 3, DNMT3B DNA methyltransferase 3B, DMP1 dentin matrix acid phosphoprotein 1, DSPP dentin sialophosphoprotein, GSK-3β glycogen synthase kinase 3, HES hairy/enhancer of split, IGF-1 insulin-like growth factor-1, JNK c-Jun N-terminal kinase, LPS lipopolysaccharide, MAPK mitogen-activated protein kinase, N2ICD Notch2 intracellular domain, NICD Notch intracellular domain, OCN osteocalcin, OPG/RANKL osteoprotegerin/receptor activator of the nuclear factor-κB ligand, OPN osteopontin, OSX osterix, RUNX2 runt-related transcription factor 2, SAHH S-adenosylhomocysteine hydrolase, SMAD3 SMAD family member 3, SPAG9 sperm-associated antigen 9, STAT3 signal transducer and activator of transcription 3, TGF-β transforming growth factor-β, TNF-α tumor necrosis factor-α, TLR-4 Toll-like receptor 4