ncRNA | Gene ID | Effects | Modes of action | Associated targets or pathways | Cell category | References |
---|---|---|---|---|---|---|
lncRNA | H19 (imprinted maternally expressed transcript) | Promotes odontogenic differentiation | (1) H19/SAHH axis | DNMT3B decreases and DLX3 increases | Human DPSCs | |
(2) H19/miR-141/SPAG9 axis | p38 and JNK MAPK pathway | Human SCAPs | Li et al. 2019 [72] | |||
lncRNA | DANCR (differentiation antagonizing nonprotein coding RNA) | Blocks odontoblast-like differentiation | GSK-3β and β-catenin suppression | Canonical Wnt/β-catenin signaling pathway | Human DPCs | Chen et al. 2016 [65] |
miRNA | miR-21 | Positively modulates odontoblastic differentiation | (1) Increasing p-STAT3 | A positive feedback loop in the miR-21/STAT3 signaling pathway | Human DPSCs | Xu et al. 2018 [50] |
(2) Increased by p-STAT3 | ||||||
miRNA | miR-143-5p | Inhibits the differentiation of human DPSCs into odontoblasts | (1) Interacting with RUNX2 3′-UTR | (1) RUNX2 suppression OPG/RANKL signaling pathway | Human DPSCs | Zhan et al. 2018 [54] |
(2) Interacting with the MAPK14 3′-UTR | (2) MAPK14 suppression p38 MAPK signaling pathway | Wang et al. 2019 [55] | ||||
miRNA | miR-140-5p | Inhibits odontogenic differentiation | Interacting with the TLR-4 3′-UTR | LPS/TLR-4 signaling pathway | Human DPSCs | Sun et al. 2017 [56] |
miRNA | miR-223-3p | Promotes odontoblastic differentiation | Interacting with the BMP4 3′-UTR | SMAD3 suppression TGF-β1 signal transduction pathway | Human DPSCs | Huang et al. 2019 [51] |
miRNA | miR-448 | Blocks odontogenic differentiation | Interacting with the MAPK1 3′-UTR | p38 MAPK signaling pathway | Human DPSCs | Yu et al. 2019 [57] |
miRNA | hsa-let-7c | Inhibits the odontogenic differentiation of IGF-1-treated human SCAPs | IGF-1/IGF-1R/hsa-let-7c axis | JNK and p38 MAPK signaling pathways | Human SCAPs | Ma et al. 2016 [32] |
miRNA | miR-34a | Promotes odontogenic differentiation | (1) Interacting with NOTCH2 and HES1 3′-UTR | Crosstalk between miR-34a and Notch signaling | Human SCAPs | Sun et al. 2014 [52] |
(2) Activated by Notch signaling |