Table 2 Various concentrations of RSV exert different effects on MSCs in vivo
From: The application of resveratrol to mesenchymal stromal cell-based regenerative medicine
RSV dosage | MSC source | MSC dose | Injury/disease | Model | Mechanism | Effect | Reference |
|---|---|---|---|---|---|---|---|
10 mg/kg | Bone marrow | 1 × 106 | CBDL | Rat | Upregulate the level of SIRT1 and downregulate the level of p53, upregulate the homing of MSCs to the liver, and decrease the homing of MSCs to the lung and spleen | Eliminate liver cirrhosis | [62] |
100 mg/kg | Bone marrow | 1 × 106 | Partial hepatectomy | Rat | Increase the homing of MSCs to the liver | Enhance liver regeneration | [63] |
200 mg/kg | Umbilical cord | 1 × 106 | Transgenic Alzheimer’s disease mouse model | Mouse | Increase the engraftment of MSCs | Improve learning and memory, enhance neurogenesis, and alleviate neural apoptosis in the hippocampus in an Alzheimer’s disease mouse model | [64] |
200 mg/kg | Umbilical cord | 1 × 106 | Alzheimer’s disease | Mouse | Increase the expression of hippocampal SIRT1, PCNA, p53, ac-p53, p21, and p16 | Increase the neurogenesis of MSCs | [64] |
100 mg/kg | Adipose tissue | 2 × 106/kg | Doxorubicin-induced injury | Rat | Enhance the cardiogenic differentiation and paracrine effects of MSCs | Prevent doxorubicin-induced cardiomyopathy | [65] |
20 μM (pretreatment) | Umbilical cord | 1 × 106 | Cisplatin-induced injury | Rat | Upregulate the secretion of PDGF-DD and increase the phosphorylation of ERK | Downregulate the apoptosis of renal tubular cells, upregulate the angiogenesis of endothelial cells, and decrease kidney injury | [66] |
30 mg/kg | Bone marrow | 1.5 × 106 | Mycobacterium tuberculosis H37Ra and pertussis toxin injury | Mouse | Suppress the release of proinflammatory cytokines (IFN-γ and TNF-α) and increase the release of anti-inflammatory cytokines (IL-4 and IL-10) | Reduce the clinical scores of patients with autoimmune encephalomyelitis | [67] |