Fig. 11

hADSC-related gene-regulatory network in “ECM-receptor interaction.” a Heat map of core differentially expressed genes in the gene set KEGG “ECM-receptor interaction” pathway. The colors in the heat map represent gene expression level (log10(TPM+1)). Red represents higher expression, blue represents lower expression. b Expanded view of the network imported from Cytoscape, where nodes represent core difference gene in the gene set KEGG “ECM-receptor interaction” pathway and edges the interaction. Node size represents “betweenness centrality,” node color represents “degree.” c–l Comparison of the results of 10 genes obtained using RNAseq and qRT-PCR methodology. Relative gene expression was evaluated by qPCR in Fs and EC treated or untreated with hADSCs. Results were normalized to GAPDH expression (***P < 0.001, **P < 0.005, *P < 0.05)