Fig. 4

SVF and hADSCs improve the wound healing processes in hyperglycemic mice. a Fasted basal serum glucose levels treated with hADSCs and SVF (*P < 0.05, compared to blank). b Full-thickness excisional wounds of the same 6-mm-diameter size were created on the backs of each mouse. c Photographs of wounds 0–9 days after skin injury. d Quantification of the wound area, which was measured using the long and short diameters of the wounds, at different days after wounding. (*P < 0.05, hADSCs compared to control (CON); ^#P < 0.05, SVF compared to CON). Influence of SVF and hADSCs on the expression of Endothelin1 and Leiomodin1 mRNAs. Gene expression of Endothelin1 (e) and Leiomodin1 (f) was evaluated by qRT-PCR from skin at the edges of the wounds treated or untreated with hADSCs or SVF. Results were normalized to GAPDH expression. (Statistical significance of the differences is indicated by ***P < 0.001, **P < 0.005, and *P < 0.05)