Fig. 4

Overview of RD-LPS-induced release of bone marrow-derived small EVs with IFITM3 cargo. C57/Bl mice were injected i.p. with RD-LPS. After 24 h, the amount of EPCs (depicted as orange cells with gray nuclei) were elevated both in the bone marrow and peripheral blood, potentially playing a role in the vascular regeneration of distant damaged tissues. Small EVs (dark pink dots) isolated from bone marrow cells presented upregulated IFITM3 expression (light blue)