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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: NT3P75-2 gene-modified bone mesenchymal stem cells improve neurological function recovery in mouse TBI model

Fig. 5

Overexpression of NT3P75-2 promotes the survival of transplanted BMSCs after TBI. a The representative images of GFP staining of BMSCs at 1 day after transplantation in different groups (GFP-BMSCs, NT3-BMSCs, NT3P75-2-BMSCs). The nuclei are stained by DAPI. The dotted line indicated the brain injury area (scale bar, 100 μm). b Quantification analysis of GFP-positive cells in each group (GFP-BMSCs, NT3-BMSCs, NT3P75-2-BMSCs) (n.s.,no significance, n = 4). c The representative images of GFP staining of BMSCs at 3 days after transplantation in different groups (GFP-BMSCs, NT3-BMSCs, NT3P75-2-BMSCs). The nuclei are stained by DAPI. The dotted line indicated the brain injury area (scale bar, 100 μm). d Quantification analysis of GFP-positive cells in each group (GFP-BMSCs, NT3-BMSCs, NT3P75-2-BMSCs) (#P < 0.05, ***P < 0.001 by one-way ANOVA followed by Bonferroni’s multiple comparison rest, n = 4). e The representative images of GFP staining of BMSCs at 7 days after transplantation in different groups (GFP-BMSCs, NT3-BMSCs, NT3P75-2-BMSCs). The nuclei are stained by DAPI. The dotted line indicated the brain injury area (scale bar, 100 μm). f Quantification analysis of GFP-positive cells in each group (GFP-BMSCs, NT3-BMSCs, NT3P75-2-BMSCs) (##P < 0.01, ***P < 0.001 by one-way ANOVA followed by Bonferroni’s multiple comparison test, n = 4). g The diagram indicates the area for image capture

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