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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Extracellular vesicles derived from human Wharton’s jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

Fig. 1

Characterization of hMSC-EVs. a Nanoparticle tracking analysis of hMSC-EVs indicates a mixed population of exosomes and microvesicles, comprising particles with diameters ranging between 30 and 750 nm and an average particle density of 1.7 ± 0.7 × 104 particles/cell (n = 3 EV preparations from independent cord donors). b hMSC-EVs were positive for MSC markers CD73, CD90, CD105 and negative for HLA-DR, CD14, CD34, CD45, and CD146. c CD63-positive exosomes isolated from the total population of hMSC-EVs by CD63-conjugated capture beads are positive for exosome-associated tetraspanins, CD9 and CD81. d, e Representative TEM images of hMSC-EVs. White arrows indicate exosomes; black arrows indicate microvesicles

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Stem Cell Research & Therapy

ISSN: 1757-6512