Fig. 2

AβOs promote uptake of hMSC-EVs by hippocampal cells. Double-labeled hMSC-EVs (Vybrant DiI shown in red; SYTO RNA shown in green) were incubated for 24 h with hippocampal cultures after a previous 24-h exposure of cultures to vehicle (b) or 500 nM AβOs (c). Control hippocampal cultures in the absence of fluorescent hMSC-EVs showed no labeling (a). Scale bar, 20 μm