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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

Fig. 3

rhMG53 crosses the blood-brain barrier and enhances the migration of hUC-MSCs in the brains of TBI mice. a The timeline for animal experiments. b Western blot of MG53 in mouse brains following TBI. c Densitometric analysis of MG53 protein levels from multiple mice. d PCR results of the human-specific DNA (479 bp) in the hippocampus of the TBI mice. e Quantification of the PCR results for human-specific DNA in mouse hippocampus. f Representative images of immunohistochemical staining with MAB1281 to identify the content of hUC-MSCs in the hippocampus. Scale bar = 100 μm. g Quantification of MAB1281+ cells in the hippocampus. Data are presented as mean ± SEM. n = 6 per group. *p < 0.05, compared with TBI group; #p < 0.05, compared with MG53 + MSC group

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