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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: A comparison of BMP2 delivery by coacervate and gene therapy for promoting human muscle-derived stem cell-mediated articular cartilage repair

Fig. 3

MicroCT 3D images and knee joint space quantification. ae Representative MicroCT images of knee joints for non-injured and injured sides of each group. It is obvious that there is cartilage erosion in the injured side and that the femoral condyle and trochlear groove cartilage are exposed compared to that of the non-injured side for all 5 groups. Subchondral cancellous bone is visible in the injured side. All of the hMDSC-treated groups appeared to be smoother than the PBS group. Pink arrows pointed to joint empty space; yellow arrows pointed to cartilage erosion. f Quantification of knee joint space differences between non-injured and injured sides among groups. The joint space differences between non-injured knees and injured knees were significantly smaller in the hMDSC-LBMP2/GFP group and the BMP2 + sFLT1 + coacervate+ hMDSC-LGFP group when compared to the PBS group. No significant differences were found for the other groups. *P < 0.05, Wilcoxon rank-sum test

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