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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: A comparison of BMP2 delivery by coacervate and gene therapy for promoting human muscle-derived stem cell-mediated articular cartilage repair

Fig. 6

Col2 staining. Brown color showed Col2-positive cartilage matrix. We observed very few chondrocytes in the PBS + coacervate group, and the residual matrix was Col2A1-positive. The BMP2 + hMDSC-LGFP group showed chondrocyte regeneration, although only partial, and Col2A1 staining was positive in certain areas. In the hMDSC-LBMP2/GFP group, Col2-positive chondrocytes were found in cluster. In the BMP2 + coacervate + hMDSC-LGFP group, Col2-positive chondrocytes distributed mainly on the superfacial zone and middle zone, zones near tide marker showed no chondrocytes. The BMP2 + sFLT1 + hMDSC-LGFP group showed slightly better chondrocytes distribution than the hMDSC-LBMP2/GFP group and BMP2 + coacervate+ hMDSC-LGFP group. Scale bar = 100 μm

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