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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis

Fig. 2

Therapeutic effect of BMSC-derived exosomes on POF. a Protocol for mouse model of POF. b HE staining of ovarian tissue was performed to observe the morphological differences of follicles (under (× 100) magnification, arrows point to atretic follicles). c The difference in the expression of cleaved-caspase3 in the ovarian tissue was analyzed by immunohistochemistry (scale bar, 5.0 μm) *P<0.05 vs.control group, #P<0.05 vs. POF group. d The difference expression of P53 in the ovarian tissue was detected by Western blot. e The concentration of E2 in the serum was detected by ELISA **P<0.01 vs.control group, ##P<0.01vs. POF group. Data are expressed as mean ± standard deviation (SD)

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