Table 2 Exosome derived from various types of stem cells and arthritis
From: Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
Cargo | Composition of cargo | Type of arthritis | Type of stem cell | Model | Function | Ref |
|---|---|---|---|---|---|---|
Protein | CD9, CD63, and TSG101 | OA | SMMSC and iMSCs | Mice | Induce the chondrocyte migration and proliferation | [38] |
Non-coding RNA | miR-92a-3p | OA | MSCs | Mice | Modulate the development of cartilage and homeostasis via direct targeting and inhibition of WNT5A | [37] |
miR-320c | OA | hBMSCs | In vitro | Downregulate the MMP13 and up regulate SOX9)expression | [105] | |
miR-140-5p | OA | SMSCs | Rat | Improve the proliferation and migration of articular chondrocytes and prevent OA | [90] | |
miR-150-5p | RA | MSCs | Mice | Decrease joint destruction though inhibiting the synoviocyte hyperplasia and angiogenesis | [106] | |
lncRNA-KLF3-AS1 | OA | MSCs | Rat | Inhibit IL-1β-induced apoptosis of chondrocytes | [107] | |
Not mentioned | Not mentioned | OA | MSCs | Rabbit | Inhibit the phosphorylation of p38 and ERK and induces the phosphorylation of Akt | [108] |
Not mentioned | Not mentioned | OA | MSCs | Rat | Improve the synthesis of s-GAGOmpedes by IL-1β, and inhibits the IL-1β-induced nitric oxide and MMP13 production | [109] |
Not mentioned | Not mentioned | OA | AD-MSCs | In vitro | Decrease the generation of inflammatory mediators such as TNF-α, IL-6, PGE2, and NO and improve the generation of the anti-inflammatory cytokine IL-10 | [110] |
Not mentioned | Not mentioned | OA | AD-MSCs | In vitro | Downregulate the SABG activity and. Reduce the generation of inflammatory mediators. | [111] |
Not mentioned | Not mentioned | OA | BM-MSCs | Mice | Induce the type II collagen, and aggrecan expression, inhibit the expression of the MMP-13, ADAMTS5, and iNOS | [2] |
Not mentioned | Not mentioned | OA | ESC-MSCs | Mice | Augment the synthesis of collagen type II and reduce the expression of ADAMTS5 in the presence of IL-1β | [36] |
Not mentioned | Not mentioned | Collagen-Induced Arthritis | MSCs | Mice | Anti-inflammatory role on T and B-lymphocytes | [112] |
Not mentioned | Not mentioned | Antigen-induced synovitis | MSCs | Pig | Reduce the synovial lymphocytes together with a down modulation of TNF-α transcripts | [113] |