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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

Fig. 5

MSC-secreted TGF-β activated Akt/FoxO1 signalling in LPS-stimulated macrophages. a The protein expression levels were tested with antibody microarray analysis. b Western blot analysis revealed that there were significant increases in the phosphorylation levels of Akt and FoxO1 in the MSC groups compared to those in the LPS-stimulated groups, while TGF-β Ri decreased the phosphorylation levels of Akt and FoxO1 (n = 3). MSC, mesenchymal stem cell; PMA, peritoneal macrophages; TGF-β Ri, TGF-β receptor inhibitor

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