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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

Fig. 7

Effect of FoxO1 inhibitor on LPS-treated macrophage polarization in response to MSC treatment. Macrophages were treated with or without AS1842856 (10 nM), followed by stimulation with LPS (500 ng/ml) or MSCs for 48 h. a The effect of AS1842856 on FoxO1 was tested by WB. b The effect of AS1842856 on the LPS-treated RAW264.7 and peritoneal macrophages phenotype in response to MSCs treatment was tested by WB. c The effect of AS1842856 on the LPS-treated RAW264.7 and peritoneal macrophages phenotype in response to MSC treatment was tested by flow cytometry. The results are presented as the mean ± SD (n = 3). ###p < 0.001 vs. LPS group; &&p < 0.01 vs. MSCs+LPS group; &&&p < 0.001 vs. MSCs+LPS group. AS1842856, FoxO1 inhibitor; LPS, lipopolysaccharide; MSCs, mesenchymal stem cells; WB, Western blot

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Stem Cell Research & Therapy

ISSN: 1757-6512