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Fig. 11 | Stem Cell Research & Therapy

Fig. 11

From: In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor

Fig. 11

The comparison of the cell fate of induced neural stem cells (iNSC) in the Mock and Zfp-GFP groups at 6 weeks post-transduction (WPT). a Experimental design. SCI, spinal cord injury; IHF, immunohistofluorescence; W, weeks. b Representative images of Gfap staining for spinal cord sections in the Mock and Zfp groups. c Immunostaining of the spinal cord in the Mock group at 6 WPT. Micrographs showing merges of DAPI/GFP with Gfap (astrocytes), Nestin (neural stem cells), Dcx (neuroblasts), and Map2 (mature neurons) after 6 weeks. d Fluorescence intensity after immunostaining for Gfap. e Quantitative analysis of immunofluorescence staining for the Mock and Zfp group. Mean is shown for n = 3 animals in each group. Data are represented mean ± SD. Data were analyzed by the unpaired t test. **p < 0.01; ***p < 0.001. The number of counted cells is presented in Additional file 4: Table S3

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Stem Cell Research & Therapy

ISSN: 1757-6512