Applications of miRNAs in cardiac development, disease progression and regeneration

Table 1 miRNA with known targets and their functions in animal models

miRNA	Animal model	Target	Function	References
miR-1	Mice	Hand2	Downregulate ventricular cardiomyocytes expansion, promote cardiac differentiation	[51]
	Mice	Delta-1	Promotes mesoderm formation, cardiac lineage determination	[48]
	Drosophila	Delta	Regulates expansion of cardiac and muscle progenitor cells	[56]
miR-17-92	Mice	Isl1, Tbx1	Regulation proliferation of cardiac progenitors	[53]
miR-130a	Mice	Fog-2	Regulates myocardium growth	[54]
miR-133a	Mice	Serum response factor, cyclin D2	Negatively regulate cardiomyocyte proliferation	[50]
miR-138	Zebrafish	Cspg2	Regulates ventricular cardiomyocyte maturation	[55]

ISSN: 1757-6512