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Table 1 miRNA with known targets and their functions in animal models

From: Applications of miRNAs in cardiac development, disease progression and regeneration

miRNA Animal model Target Function References
miR-1 Mice Hand2 Downregulate ventricular cardiomyocytes expansion, promote cardiac differentiation [51]
Mice Delta-1 Promotes mesoderm formation, cardiac lineage determination [48]
Drosophila Delta Regulates expansion of cardiac and muscle progenitor cells [56]
miR-17-92 Mice Isl1, Tbx1 Regulation proliferation of cardiac progenitors [53]
miR-130a Mice Fog-2 Regulates myocardium growth [54]
miR-133a Mice Serum response factor, cyclin D2 Negatively regulate cardiomyocyte proliferation [50]
miR-138 Zebrafish Cspg2 Regulates ventricular cardiomyocyte maturation [55]