Fig. 7
From: Flow-enhanced priming of hESCs through H2B acetylation and chromatin decondensation
Working model of flow-induced hESC priming. H2B acetylation level is low under static control (a). Fluid shear increases the nuclear area via CFL2/F-actin cytoskeletal remodeling (biomechanical signaling) and then enhances the chromatin decondensation via H2B acetylation (biochemical signaling) (b). In succession, chromatin decondensation enforces the nucleolus formation but softens the nucleus, while H2B acetylation is correlated negatively with cell-cell contact (c). Consequently, chromatin accessibility to transcription factors is enhanced in hESCs to consolidate their primed state (d)