Fig. 5

The invasion ability and TMZ resistance of NADH^high glioma cells are similar to the ability of CD133⁺ and CD15⁺ subpopulation in glioma cells. a The quantitative histograms of invasion showed that invasion ability was significantly increased in NADH^high, CD133⁺, and CD15⁺ LN229 and GBM1 cells. b Effect of TMZ resistance in CD133, CD15, and NADH. IC50 of TMZ in CD133⁺ and NADH^high was higher than in CD133⁻, and NADH^low of GBM1 and LN229. The similar result was in CD15 of GBM1, but IC50 of TMZ in CD15 of LN229 was not different. All data are presented as the means ± SD. **p < 0.01, ***p < 0.001 (n = 3 independent experiments)