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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells

Fig. 3

Effect of cell survival and death pathway in senescent PD-MSCs during long-term cultivation. a The expression of p-AKT/AKT and p-ERK1/2 gene related to survival pathway were analyzed by Western blot in early and late passage PD-MSCs. b The expression of Bax and Bcl2 gene related to pro-/anti-apoptosis regulator were analyzed by Western blot in early and late passage PD-MSCs. c The gene expression of p-mTOR/mTOR, PI3K-p100/-p85, ATG 5–12, and LC3 I/II related to autophagy pathway was analyzed by Western blot in early and late passage PD-MSCs. The data were representative of three independent experiments and presented by Image J software and expressed as means ± S.D. An asterisk indicates P < 0.05 versus early passage

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