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Table 1 List of genes included in NanoString Codeset

From: Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues

Gene symbol

Gene name

Fold change*

p value

ACTA1

Actin, Alpha 1, Skeletal Muscle

2.35

0.0030

ACTA2

Actin, Alpha 2, Smooth Muscle, Aorta

1.17

0.3664

ACTN2

Actinin Alpha 2

1.00

0.9877

ADRB1

Adrenoceptor Beta 1

1.39

0.2645

ADRB2

Adrenoceptor Beta 2

1.35

0.2586

ADRB3

Adrenoceptor Beta 3

0.84

0.7008

AGTR1

Angiotensin II Receptor Type 1

0.34

0.0214

ATP2A2

ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2

0.95

0.6659

BAX

BCL2 Associated X, Apoptosis Regulator

1.11

0.6011

BCL2

BCL2, Apoptosis Regulator

0.57

0.1837

BCL2L1

Apoptosis Regulator Bcl-X

1.08

0.7545

BCL2L2

Apoptosis Regulator Bcl-W

0.88

0.5770

CACNA1C

Voltage-Gated L-Type Calcium Channel Cav1.2 Alpha 1 Subunit

1.06

0.8099

CASP3

Caspase 3

0.79

0.0175

CASP8

Caspase 8

0.70

0.4188

CASP9

Caspase 9

1.05

0.8472

CASQ2

Calsequestrin 2

0.49

0.0902

CD34

CD34 Molecule

1.15

0.1137

CD44

CD44 Molecule (Indian Blood Group)

2.28

0.2705

CDK1

Cyclin Dependent Kinase 1

0.39

0.0043

CNTN2

Contactin 2

0.53

0.2429

COL1A1

Collagen Type I Alpha 1 Chain

2.18

0.0254

COL3A1

Collagen Type III Alpha 1 Chain

1.74

0.0151

CTGF

Connective Tissue Growth Factor

1.13

0.5425

DDR2

Discoidin Domain Receptor Tyrosine Kinase 2

0.86

0.5965

ENG

Endoglin (CD105)

2.04

0.1706

GATA 4

GATA-Binding Factor 4

1.25

0.0533

GJA1

Connexin-43 (Gap Junction Protein Alpha 1)

0.88

0.2805

GJA5

Gap Junction Protein Alpha 5 (Connexin 40)

0.58

0.1210

HCN1

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1

0.40

0.0024

HCN2

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2

1.43

0.6689

HCN3

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3

0.95

0.9201

HCN4

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4

1.16

0.4744

IRX4

Iroquois Homeobox 4

0.96

0.7108

JUP

Junction Plakoglobin

1.01

0.9708

KCNH2

HERG1 - Ether-A-Go-Go-Related Gene Potassium Channel 1

1.12

0.6170

KCNQ1

Potassium Voltage-Gated Channel Subfamily Q Member 1 (Kv7.1)

1.87

0.1707

MESP1

Mesoderm Posterior BHLH Transcription Factor 1

2.34

0.3436

MYC

C-Myc

1.73

0.3395

MYH6

Myosin Heavy Chain 6

0.74

0.0216

MYH7

Myosin Heavy Chain 7

1.24

0.2239

MYL2

Cardiac Ventricular Myosin Light Chain 2 (MLC-2v)

1.53

0.1215

MYL7

Myosin Regulatory Light Chain 2, Atrial Isoform (MLC-2A)

0.69

0.0009

NFATC1

Nuclear Factor Of Activated T Cells 1

2.19

0.1411

NKX2–5

Cardiac-Specific Homeobox

1.19

0.1061

NPPA

Natriuretic Peptide A

1.78

0.0013

NPPB

Natriuretic Peptide B

1.64

0.0154

PECAM1

Platelet And Endothelial Cell Adhesion Molecule 1 (CD31)

1.55

0.1507

PLN

Phospholamban

1.37

0.0199

POSTN

Periostin

3.82

0.1770

RYR2

Ryanodine Receptor 2

0.82

0.0621

SLC8A1

Sodium/Calcium Exchanger 1 (NCX1)

1.09

0.1813

TGFB1

Transforming Growth Factor Beta 1

2.14

0.0262

TNNI1

Troponin I1, Slow Skeletal Type

0.98

0.9204

TNNI3

Troponin I3, Cardiac Type

1.90

0.0009

TP53

Tumor Protein P53

1.01

0.9708

VIM

Vimentin

0.86

0.2823

WT1

Wilms Tumor 1

0.56

0.1367

  1. Listed alphabetically according to gene symbol. Expression level (fold change relative to control*) and p value for hCSC-supplemented hECTs normalized to hCM-only control hECTs
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Stem Cell Research & Therapy

ISSN: 1757-6512