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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cells induce dendritic cell immune tolerance via paracrine hepatocyte growth factor to alleviate acute lung injury

Fig. 6

Effects of MSCs on pulmonary DCs in ALI mice by secreting HGF. a Immunophenotype analysis of pulmonary DCs in ALI mice treated with transfected or untransfected MSCs. Representative dot plots and bar graph showing the percentage of respiratory cDCs (gate on the upper right quadrant) in the presence of normal saline, MSCs, NC-HGF-MSCs, HGF-MSCs, NC-shHGF-MSCs, and shHGF-MSCs. b Charts and bar graph showing the expression of MHCII on respiratory cDCs (gate on the right in each panel, M1). Pulmonary cDC phenotype changes were statistically analyzed. c Charts and bar graph showing the expression of CD86 on respiratory cDCs (gate on the right in each panel, M2). Pulmonary DC phenotype changes were statistically analyzed. d Representative histology sections of lung tissue at 24 h (hematoxylin and eosin staining; magnification, ×200) and the pathological lung injury score at 24 h. e Comparison of the lung wet weight to body weight ratio (LWW/BW) in different groups at 24 h. These data are expressed as the mean ± SD (n = 5, for each group at 24 h, *P < 0.05 versus the Con group; #P < 0.05 versus the ALI mice, &P < 0.05 versus the NC-HGF-MSC mice; $P < 0.05 versus the NC-shHGF-MSC mice; data are expressed as the mean ± SD)

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