TY - JOUR AU - Grinnemo, Karl-Henrik AU - Löfling, Marie AU - Nathanson, Lubov AU - Baumgartner, Roland AU - Ketelhuth, Daniel F. J. AU - Beljanski, Vladimir AU - Davies, Lindsay C. AU - Österholm, Cecilia PY - 2019 DA - 2019/12/04 TI - Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells JO - Stem Cell Research & Therapy SP - 371 VL - 10 IS - 1 AB - Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As early gestational-phase embryonic tissues exhibit extraordinary regenerative potential, fetal MSCs exposed to inflammation offer a unique opportunity to evaluate molecular mechanisms underlying preferential healing, and investigate their inherent abilities to communicate with the immune system during development. The principal aim of this study was to evaluate the effects of interferon-γ (IFNγ) on the immunomodulatory effects of first-trimester human fetal cardiac (hfc)-MSCs. SN - 1757-6512 UR - https://doi.org/10.1186/s13287-019-1489-1 DO - 10.1186/s13287-019-1489-1 ID - Grinnemo2019 ER -