Fig. 3

fMSCs decreased oxidative damage, increased oxidative protection, improved anti-apoptosis rates, and inhibited apoptosis in POI hGCs. a fMSCs were seeded on the upper coculture inserts, while POI hGCs were seeded on the bottom of a six-well culture plate. b FACS analysis of ROS expression at 8 weeks in different treatment groups. c–h ELISA analysis of MDA, SOD, CAT, LDH, GR, and GPx levels at 8 weeks in different treatment groups. i qPCR analysis of SURVIVIN and BCL2 in different treatment groups. j qPCR analysis of CASPASE3 and CASPASE9 in different treatment groups. k Western blot analysis of SURVIVIN, BCL2, CASPASE3, and CASPASE9 in different treatment groups. Data are represented as the mean ± SD. ***p < 0.001 (compared with the NG group)