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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Magnesium-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells by activating ERK/BMP2/Smads signaling

Fig. 4

Mg2+-enriched microenvironment promotes odontogenic differentiation in DPSCs by increasing intracellular Mg2+. a Intracellular Mg2+ was significantly increased in DPSCs exposed to high extracellular Mg2+ as assessed flow cytometrically using Mag-Fluo-4-AM; however, there was no difference between the 5 and 10 mM Mg2+ groups. b Mg2+-entry was significantly inhibited by the TRPM7 inhibitor 2-APB. c The positive effect of Mg2+-enriched microenvironment on odontogenic differentiation in DPSCs was also blocked by 2-APB

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