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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Magnesium-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells by activating ERK/BMP2/Smads signaling

Fig. 7

Mg2+-enriched microenvironment promotes odontogenic differentiation in DPSCs via ERK/BMP2/Smads signaling. a After treatment with U0126, the protein amounts of RUNX2, DSP, and DMP-1 were markedly decreased in DPSCs treated with high extracellular Mg2+. b Consistently, mineralization nodules were also reduced. c After treatment with U0126, BMP2, BMPR1, and phosphorylated Smad1/5/9 protein amounts were significantly decreased, indicating that BMP2/Smads signaling acted as downstream of ERK

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Stem Cell Research & Therapy

ISSN: 1757-6512