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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: SOX19b regulates the premature neuronal differentiation of neural stem cells through EZH2-mediated histone methylation in neural tube development of zebrafish

Fig. 3

Effect of Sox19b on NSCs in neural tubes. a H&E histological sections of the brain and spinal cord of zebrafish embryos at 24 hpf showed that the number of cells and cell layers in the neural tube decreased, and the ventricle expanded in the Sox19b MO-injected embryos compared with controls. b BrdU labelling of control MO- and Sox19b MO-injected embryos at 24 hpf. Data represent the mean of at least three independent experiments ± SD. **P < 0.01 versus control. c The expression of PCNA was detected by whole-mount in situ hybridization, and the expression was used to detect proliferating cells in zebrafish embryos of control MO MO- and Sox19b MO-injected embryos. d Immunolabelling of HuC (early neuronal marker) at 24 hpf showed that the expression of HuC was ectopic in Sox19b morphants, and the expression of HuC appeared in some regions that were enriched with NSCs. Data represent the mean of at least three independent experiments ± SD. *P < 0.05 versus control

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Stem Cell Research & Therapy

ISSN: 1757-6512