Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction

Fig. 7

Diagrammatic depiction of EMF-induced upregulation of P2X7 expression and the downstream pro-osteogenesis effect. P2X7 expression is upregulated in h-MSCs exposed to EMFs during osteogenic differentiation. The EMF-induced upregulation of P2X7 can be activated by P2X7 agonists, ATP or BzATP. P2X7 ligation activates the Akt/GSK3β/β-catenin axis to induce osteogenic differentiation of MSCs (accompanied by upregulated expression of osteogenic markers) and inhibit osteoporosis

Back to article page