Fig. 2From: The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptorDomain structure of hGR splice variants and isoforms. The primary transcript of hGR consists of nine exons. Exon 1 constitutes the 5′-untranslated region (5′UTR), whereas the protein-coding region is made up of exons 2 to 9. In this process, the A/B-domain or NH2-terminal transactivation domain (NTD) containing the ligand-independent activation function 1 (AF-1) is encoded primarily by exon 2, the C-domain with the DNA-binding domain (DBD) is encoded by exons 3 and 4, and the D-domain or hinge region involved in nuclear localization is encoded by exon 5, while the other exons (up to exon 9) encode the E-domain including the ligand-binding domain (LBD) and a nuclear localization signal, which participates in the dimerization and Hsp90 bindingBack to article page