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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

Fig. 2

Domain structure of hGR splice variants and isoforms. The primary transcript of hGR consists of nine exons. Exon 1 constitutes the 5′-untranslated region (5′UTR), whereas the protein-coding region is made up of exons 2 to 9. In this process, the A/B-domain or NH2-terminal transactivation domain (NTD) containing the ligand-independent activation function 1 (AF-1) is encoded primarily by exon 2, the C-domain with the DNA-binding domain (DBD) is encoded by exons 3 and 4, and the D-domain or hinge region involved in nuclear localization is encoded by exon 5, while the other exons (up to exon 9) encode the E-domain including the ligand-binding domain (LBD) and a nuclear localization signal, which participates in the dimerization and Hsp90 binding

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