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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation

Fig. 7

Aspirin inhibits osteoclasts during early inflammation in the rat mandibular bone defect model. a–d TRAP staining showed that by the 5th day after surgery, osteoclasts were increased in both the control group and aspirin group. e–h We performed immunohistochemical staining on sections, and the results indicated overexpression of CD11c (brown-yellow color) in both the control and aspirin groups. i However, compared to the control group, the aspirin group maintained lower osteoclast numbers (P < 0.05). j After surgery, CD11c+ cells showed a lower ratio in the aspirin group (P < 0.05). All experiments are representative of three replicates. *P < 0.05, **P < 0.01. Scale bar = 200 μm in a, c; scale bar = 100 μm in e, g; scale bar = 50 μm in b, d, f, h

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