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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Current understanding of the administration of mesenchymal stem cells in acute kidney injury to chronic kidney disease transition: a review with a focus on preclinical models

Fig. 1

Adaptive and maladaptive response in TECs after AKI. Under certain circumstances, injured TECs are able to dedifferentiate, migrate, proliferate, and finally redifferentiate into normal TECs, promoting renal recovery (blue arrows). While AKI is severe or episodes are frequent, TECs may lose their regenerative capacity and undergo maladaptive repair. The major pathophysiological alterations during this process include capillary rarefaction, mitochondrial injury and metabolic disorder, epigenetic alterations, persistent inflammation, and other effects. These changes may interact with each other and can ultimately result in profibrogenic signal production, fibroblast/myofibroblast expansion, and failed renal recovery (red arrows)

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Stem Cell Research & Therapy

ISSN: 1757-6512