Table 1 Evidence suggesting the beneficial effects of MSCs on the AKI-CKD transition
References | Year | Animal | Model | Renal outcomes |
|---|---|---|---|---|
Zhu et al. [84] | 2017 | Mice | Unilateral I/R injury | ↓Fibrosis; ↑kidney weight and size; ↓α-SMA and collagen-I; ↓TGF-β1/Smad3 |
Masoud et al. [85] | 2012 | Rats | Unilateral I/R injury | ↓Fibrosis |
Semedo et al. [86] | 2010 | Mice | Unilateral I/R injury | ↓Fibrosis; ↓proteinuria; ↑renal areas; ↓a-SMA, vimentin, and FSP-1 |
Gatti et al. [88] | 2011 | Rats | Unilateral I/R injury with contralateral nephrectomy | ↑Renal function; ↓fibrosis; ↓proteinuria |
Du et al. [90] | 2012 | Rats | Unilateral I/R injury with contralateral nephrectomy | ↑Renal function; ↓fibrosis |
Zou et al. [89] | 2014 | Rats | Unilateral I/R injury with contralateral nephrectomy | ↑Renal function; ↓fibrosis; ↓α-SMA |
Alfarano et al. [91] | 2012 | Rats | Unilateral I/R injury with contralateral nephrectomy | ↑Renal function; ↓fibrosis and tubular dilation; ↓α-SMA and MMP2 |
Zhou et al. [93] | 2016 | Rats | Unilateral I/R injury with contralateral nephrectomy | ↑Renal function; ↓fibrosis; ↓α-SMA; ↓microvascular rarefaction |
Tögel et al. [94] | 2009 | Rats | Bilateral I/R injury | ↑Renal function; ↓fibrosis; ↓PAI-1 and TGF-β |
Du et al. [96] | 2013 | Rats | Bilateral I/R injury | ↓Fibrosis |
Rodrigues et al. [97] | 2017 | Rats | Bilateral I/R injury | ↑Renal function; ↓FENa; ↓urinary concentrating defect; ↓renal damage score; ↓senescence |