Fig. 2
ESCs-sEVs contributed to the estrous cycle, body weight, and hormone levels in mice. A Estrous cycle of mice: (a) proestrus, (b) estrus, (c) metestrus, and (d) diestrus. B The weight of mice with ESCs-sEVs gradually increased to normal levels, while the weight of the CTX + BUS group gradually decreased to stable levels. The dashed line indicates mice that received treatment for 14 days. C E2 was significantly increased compared to the CTX + BUS group. D FSH was significantly decreased compared to the CTX + BUS group. E AMH was significantly increased compared to the CTX + BUS group. Scale bars = 100 μm. (Data are presented as the mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001; ns, no significance)