Fig. 6

KLF4 and TGFBR2 are targets of miR-145. a The predicted binding sites between miR-145 and KLF4 are shown, and luciferase reporter assay results are shown for BMSCs transfected with a reporter containing a KLF4 3′UTR (wild-type/mutant) and a miR-145 (NC/mimic). b The predicted binding sites between miR-145 and TGFBR2 are shown, and luciferase reporter assay results are shown for BMSCs transfected with a reporter containing a TGFBR2 3′UTR (wild-type/mutant) and a miR-145 (NC/mimic). *P < 0.05, **P < 0.01. c The diagram of a proposed mechanism is shown