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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Melatonin promotes the BMP9-induced osteogenic differentiation of mesenchymal stem cells by activating the AMPK/β-catenin signalling pathway

Fig. 6

Melatonin works synergistically with BMP9 to promote osteogenic differentiation of C3H10T1/2 cells via the AMPK/β-catenin pathway. a Effect of melatonin combined with BMP9 on the AMPK/β-catenin pathway. b siAMPK inhibits the phosphorylation of β-catenin in cells co-treated with melatonin combined with BMP9. c siAMPK or d siβ-catenin has a highly potent silencing effect. e, f siAMPK or siβ-catenin abolished the ALP activity induced by melatonin combined with BMP9. Compared with the BMP9 group, ^^^p < 0.001; compared with the melatonin/BMP9 group, ***p < 0.001. g, h ALP histochemical staining was performed to verify the results. i, j Effect of siAMPK or siβ-catenin on the BMP9/Smad1/5/8 pathway

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